Effect of intravenous infusion dead space on time to drug delivery in infants

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The delivery of drugs to patients by continuous intravenous infusion: modeling predicts potential dose fluctuations depending on flow rates and infusion system dead volume.

IV drug infusion has the potential for dosing errors, which arise from complex interactions between carrier flows and the infusion set dead volume. We computed the steady-state mass of drug stored in the infusion set dead volume, using phenylephrine as a model compound. The mass of drug in the dead volume increases with stock drug concentration and desired dose but decreases with carrier flow r...

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ژورنال

عنوان ژورنال: Baylor University Medical Center Proceedings

سال: 2018

ISSN: 0899-8280,1525-3252

DOI: 10.1080/08998280.2018.1444254